摘要 应用ABC免疫组化法对93例膀胱移行细胞癌组织中的原癌基因c-erbB-2和抑癌基因P⁵³ 的表达及共同表达的意义进行了研究。结果显示：c-erbB-2和P⁵³ 的阳性表达率分别为26%和48%，二者共同表达率为21.5%，共同表达与肿瘤的病理分级(P<0.05)，临床分期(P<0.01)，复发(P<0.05)关系极为密切。提示c-erbB-2和P⁵³ 与膀胱移行细胞癌的发生、发展、尤其与肿瘤的侵袭性密切相关，并且二者可能有协调作用。同时检测两者的表达情况，可为临床判断膀胱移行细胞癌预后提供可靠的依据。

Yuan Lianxiang

    Liuzhou Neoplasm Hospital, Liuzhou, P.R.China 545005

The ABC immunohistochemical method was used instudy the expression of c-erbB-2 and protein P⁵³ in transitional cell bladdercarcinoma from 93 patients. It showed that the positive expressive rates of c-erbB and P⁵³ protein were 26% and 48% respectively, and the common expressive rate of the two was21.5%, and the common expression was closely ralated to the pathological grading(P<0.05), to the clinical stages (P<0.01), and to the recurrence (P<0.05) of thecarcinoma. It was suggested that c-erbB-2 and protein P⁵³ had close correlationto the formation and progress of the carcinoma, especially the invasive, moreover, the twomay have coordinate function. The assay of c-erbB-2 and P⁵³ may help to theclinical judgement of the prognose of transitional cell bladder carcinoma.

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