(王 琪), Xu Lu(徐 露), Qiu Xingfang(邱信芳), Xue Jinlun(薛京伦)
(Department of Neurosurgery,The First Hospital Affiliated to Suzhou Medical College,Suzhou,215006)
关键词：
Abstract Objective Toinvestigate the effects of combination adenovirus-mediated HSV-tk/GCV system and antisenseIGF-1 gene therapy for rat glioma and analyze the mechanism.Methods Using therecombinant adenovirus vector,GCV killing effeciency after combined gene transfer ofHSV-tk and antisense IGF-1 was observed in vitro.Rat glioma was treated with HSV-tk/GCVand antisense IGF-1 and the survival rate of rats was observed.Results C6 cellstransfected with tk and antisense IGF-1 gene were more sensitive to GCV than thattransfected with tk gene alone.The survival of the combination gene therapy group wasprolonged significantly and large amounts of CD+ 4 ,CD+ 8 lymphocytes were detected in the tumor tissues.Conclusion Antisense IGF-1 gene mayenhance the tumor-killing effects of HSV-tk/GCV.
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