王键 胡建鹏 安徽中医学院 合肥 230038 安徽中医学院学报 1999 0 18 2


    关键词：动物模型；缺血性中风；气虚血瘀证；脑水肿；局部脑组织血流量；血液流变学；血栓素A2；前列环素 期刊 ahzyxyxb 0 实验研究 fur -->


    

摘要 选用中老龄大鼠，采用饥饿、劳累、高脂饮食，结扎左侧颈总动脉的方法，制作缺血性中风气虚血瘀证模型。通过对一般体征、局部脑组织血流量(rCBF)、脑水肿、血液流变学、血浆血栓素A₂ (TXA₂ )、前列环素(PGI₂ )的观察，结果表明：模型鼠出现偏瘫症状；脑组织含水量显著增高(P<0.01)、脑水肿明显；rCBF显著增高，PGI₂ 显著降低(P<0.01)，血液呈高度浓、粘、凝、聚状态。符合缺血性中风气虚血瘀证的临床特点。

    中图法分类号 R-332

PRELIMINARY STUDY ON ANIMAL’S MODEL OF QI-DEFICIENCY AND BLOOD-STASIS IN ISCHEMIA STROKE

Wang Jian，Hu Jianpeng

    (Anhui College of TCM,Hefei 230038 )

ABSTRACT The ratmodel of Qi-deficiency and blood-stasis in ischemia stroke was made by usingmiddling-aging rats,hunger,tiredness,high-fat diets and the occlusion of left commoncarotid.The general signs,regional cerebral blood flow(rCBF),edema and hemorheology wereobserved.The contents of thrombox and A₂ (TXA₂ ) and prostalycline(PGI₂ )in plasma were detected.The results showed that partial paralysis was found,hemorheologicproperties and rCBF markedely lowered (P<0.01) ......