刘牧林 方先业 鲍子雨 昌茂岭 233004 蚌埠医学院附属医院急诊外科(刘牧林，方先业)；蚌埠市第一人民医院普外科(鲍子雨)；蚌埠市第三人民医院普外科(昌茂岭) 蚌埠医学院学报 1999 0 24 3


    关键词：危重病人的监护；血液凝血；纤维蛋白溶解；血小板 期刊 bbyxyxb 0 基础医学 fur -->


    

摘要 目的： 探讨外科危重病患者凝血功能障碍与病情严重度和预后的关系。方法： 71例外科危重症患者分为轻型组、重型组、死亡组，发病0、4、8 d分别检测抗凝血酶Ⅲ(AT-Ⅲ)、组织型血浆纤溶酶原激活物(t-PA)、组织型血浆纤溶酶原激活物抑制剂(PAI)、血小板α颗粒膜蛋白(GMP-140)。结果： 危重症患者凝血和纤溶系统被激活，并伴有纤溶受抑，死亡者与存活者差异有显著性(P<0.01)，并与疾病严重度和预后有一定的相关性。结论： 动态监测止凝血指标有助病情的判断和预后的估计。

Dynamic change in blood coagulation in critically ill surgical patients

Liu Mulin,Fang Xianye,Bo Ziyu,Chang Maoling

Department of Emergency Surgery,Affiliated Hospital of Bengbu Medical College,Anhui 233004

Abstract Objective:To investigate the blood coagulation disorder in critically ill surgical patients.Methods:Seventy-one cases were divided into mild,severe and dead groups.All patients were measured for AT-Ⅲ,t-PA,PAI,GMP-140 on 0,4 and 8 days after admission.Results:The coagulation and fibrinolysis were activated,and fibrinolysis was inhibited.There is a significant difference between survivors and nosurvivors(P<0.01).These changes are closely correlated with the APACHE-Ⅱ score.Conclusions:Change in coagulation parameters is important in evaluating the condition and prognosis of critically ill surgical patients.

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