关键词:佝偻病;维生素D缺乏;大鼠
摘要 目的 :观察维生素D(Vit D)突击疗法对Vit D缺乏性佝偻病的作用效果。方法 :用Wistar大鼠建立幼鼠佝偻病模型并采用4个等级剂量的Vit D3 (15万IU,30万IU,60万IU,120万IU)分别一次性肌肉注射,并与正常对照组和模型组比较,观察幼鼠身长、体重、血钙、血磷、骨X片以及骨、肾、大血管病理切片。结果 :治疗各组的体格、血生化、骨X片及骨病理学改变均恢复到正常对照组水平,经统计学处理,各实验组差异均无显著性,各组肾、腹主动脉均未见钙化灶。结论 :大剂量Vit D可用于佝偻病治疗。
中国图书资料分类法分类号 R 591.44 Q 959.837
Massive dose of vitamin D on experimental rickets
Dong Xunlan,Qian Youqiong,Xu Bo
(Department of Pediatrics,Wuhu the Second People's Hospital,Anhui 241000)
Abstract Objective :To observe the effect of a single large dose of vitamin D in treatment of rickets rats.Methods :Rickets wister rats models were experimentally established,were then divided into 4 groups.A single dose of vitamin D was injected intramus cularly in 1.5×105 IU ......
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