摘要 目的：了解胰岛素样生长因子(IGF-Ⅰ)及其结合蛋白(IGFBPs)水平在儿童肾病综合征(NS)中的变化。方法：用免疫放射法和放射免疫法对20名NS患儿，即NS活动期组(NSA组,n=11)和NS缓解期组(RE组,n=9)进行了血清IGF-Ⅰ和IGFBPs水平测定；并以同年龄组正常儿童(NC组，n=10)作对照。结果:与NC组比较，NSA组血清IGF-Ⅰ、IGFBP₃ 明显下降(P<0.01)，IGFBP₁ 和IGFBP₂ 均明显升高(P<0.01)；RE组的血清IGF-Ⅰ及IGFBP₁ 、IGFBP₂ 和IGFBP₃ 均可恢复正常；NSA组血清IGFBP₃ 与白蛋白存在明显相关关系(r=0.76，P<0.01)。结论：NS活动期存在着IGF-Ⅰ和IGFBPs的异常改变，但缓解期可完全恢复正常；IGF-Ⅰ和IGFBPs的异常改变可能与NS患儿生长障碍有关。

INSULIN-LIKE GROWTH FACTOR-Ⅰ AND IGF BINDING PROTEINS

    IN CHILDREN WITH NEPHROTIC SYNDROME

Dong Feng,Zhou Xiang,Pang Ning,et al

    (Department of Pediatics)

Abstract Objective:To observe growth retardation in children with nephrotic syndrome(NS).Methods:We measured the serum insulin-like growth factor-Ⅰ(IGF-Ⅰ) and IGF binding proteins(IGFBPs)in 20 patients with active state(NSA) and with remission state(RE) of NS by using immuno radiometric assay and radioimmunoassay. Results:Serum level of IGFBP₁ and IGFBP₂ were increased(P<0.01) ......