关键词：硅微通道；红细胞；变形性；微机械技术
摘 要 ：本文将微机械加工技术引入细胞流变学研究领域，利用集成电路光刻和异向腐蚀工艺，在硅晶体表面形成了亚微米级精度的通道，建立了一种新的硅微通道细胞流变学测量系统，可观察细胞流过微通道的全过程。实验结果表明，系统具有良好的重复性(变异系数CV<5%)，可灵敏地反映细胞流变特性的改变，可在一定程度上模拟细胞通过毛细血管的行为，并可提供较为丰富的信息。
分类号 ：R318.01; R331.1+ 41
NEW METHOD FOR MEASUREMENT OF DEFORMABILITY
OF RBCs USING MICROCHANNELS FORMED
IN A SILICON SUBSTRATE
Zheng Xiaolin Wu Nan Lu Xiao Cai Shaoxi Wu Yunpeng Peng Chenglin
(Bioengineering Research Institute, Chongqing University, Chongqing 400044)
He Lin Hu Ganyi Zheng Wo Cui Maojing
(The 24th Institute of The Ministry of Electronic Industry, Chongqing 400060)
ABSTRACT ：Method and technique of The simulation system of capillary were studied by microchannels formed in a silicon substrate. The design principle and the method were based on the micromechanical technology. The paper presented the manufacturing process of silicon microchannels. The channel grooves were measured at submicrometer accuracy, and formed by the technology of photolithography and etching for integrated circuits. The full process of the flow of cells through the microchannels can be quantitatively observed. The author also studied the reproducibility and application experiment of the method. The experimental results proved that the a new method has a good reproducibility (Coefficient of variation CV<5%). The new method was is informative, accurate, convenient and economical.
Key words ：Silicon-microchannels; Red blood cells; Deformability; Micromechanical technology▲
0 引言
实验方法及理论模型是支撑血液流变学研究的两大支柱 ......
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