谭文长 徐明瑜 谭文长(北京大学力学与工程科学系，北京 100871)；徐明瑜(山东大学生物医学工程研究中心，济南 250100) 中国生物医学工程学报 2000 0 19 1


    关键词：药物；零级释放；双动边界；近似解析解 期刊 zgswyxgcxb 0 1-6 生物力学 fur -->


    

摘 要 ：采用修正积分法，得到了药物从溶蚀性高聚物基质内释放的双动边界问题的近似解析解，给出了扩散边界和药物释放分数的计算公式及其在不同初装浓度和溶蚀速度下的计算结果，给出了药物满足零级释放的近似条件。这对研究药物从高聚物基质内的释放问题以及控释制剂的设计具有重要的意义。

    分类号 ：R318.01; R318.08

TWO MOVING BOUNDARYPROBLEM FOR RELEASE OF

    DRUG FROM AN ERODIBLE POLYMERIC MATRIX

Tan Wenchang

    (Department ofMechanics and Engineering Science, Peking University, Beijing 100871)

    Xu Mingyu

    (Research Center forBiomedical Engineering, Shandong University, Jinan 250100)

ABSTRACT： An approximateanalytical solution of two moving boundary problem for diffusional release of drug from anerodible polymeric matrix was obtained by use of refined integral method. The releasekinetics has been analyzed for an erodible matrix with perfect sink condition. Theformulations of the moving diffusion boundary and the fraction of drug release were given.The moving diffusion boundary and the fraction of drug released have been calculated withvarious drug loading levels and different erosion rates of the matrix surface. Anapproximate condition for the zero order release was provided. These results were usefulfor the clinic experiments. This investigation provided a new theoretical tool forstudying the diffusional release of drug from an erodible polymeric matrix and designingthe controlled released drug.

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