关键词:前列腺素E类,合成;输注,静脉内;外周血管疾病
摘要 目的:观察前列地尔脂微球载体制剂(凯时,北京泰德制药有限公司)对下肢慢性动脉缺血症的疗效。方法:以多中心、同步、等样本、开放性给药方法,应用前列地尔脂肪乳注射液治疗47例下肢动脉缺血症患者,采用小剂量(10 μg/d),一次静脉推注,连续14 d。于用药前后分别观察患者的间歇性跛行、皮肤感觉、静息痛和溃疡情况,并计算踝/肱指数。结果:患者间歇性跛行、皮肤感觉、静息痛、溃疡和踝/肱指数改善的有效率分别为57.5%、74.5%、81.1%、43.4%和23.5%,综合疗效评价有效率为83.0%。结论:前列地尔脂微球载体制剂治疗下肢慢性动脉缺血症效果显著,副作用低。
EFFICACY OF LIPO PGE1 IN TREATMENT OF 47 PATIENTS
WITH CHRONIC ARTERIAL ISCHEMIA OF LEG
Huang Xiaozhong,An Zheng,Zhang Baigen,et al
(Renji Hospital of Shanghai 2nd Medical University,200001)
Abstract Objective:To evaluate an efficacy of Lipo prostaglandin E1 (PGE1 ) in the treatment of chronic arterial ischemia of legs.Methods:Lipo PGE1 was adopted to treat 47 patients with chronic arterial ischemia of leg(35 patients with arteriosclerosis obliterans,seven with thromboangiitis oblitorans,five with diabetes).A dosage of 10 μg of Lipo PGE1 was given intravenously once a day,14 days for one course.Results:The efficacy of intermittent claudication,the sence of skin,resting pain,ulcer and ankle humeral index are 57.5%,74.5%,81.2%,43.4% and 23.5% respectively with a total efficacy of 83.0%.Conclusion:Lipo PGE1 can be used in the treatment of chronic arterial ischemia of legs with a marked improvement of numbness,hypesthesia,sensation of cold and pain in lower limbs.
Subject headings:prostaglandins E,synthetic;infusions,intravenous;peripheral vascular diseases
1998年2月~1998年5月间 ......
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