【摘要】 目的 了解高血压病患者在轻、中、重不同程度血压增高情况下血浆中内皮素(ET)、心钠素(ANP)、血管紧张素II(AngII)、降钙素基因相关肽(cGRP)浓度变化。方法 采用放射免疫分析方法,分组对84例高血压病患者和36例正常人的上述4种血管活性肽水平进行了检测。结果 随血压水平的升高,血浆ET、ANP、AngⅡ浓度亦升高;与平均动脉压(MAP)有良好相关性(r=0.4899,r=0.5786,r=0.3288,P<0.01-0.001);血浆cGRP水平则随血压的升高而下降，与MAP无关(r=-0.06,P>0.05)。结论 提示高血压的发生、发展与上述血浆血管活性肽水平的变化有关。

    Changes of partial plasma circulating peptides in hypertensive patients and their clinicalsignificance Jia Shaobin, Chen Shulan, Li Haiquan. The Affiliated Hospital of NingxiaMedical College, Yinchuan 750004

    【Abstract】 Objective To measure the levels of plasma endothelin (ET), atrialnatriuretic peptide (ANP), angiotensionⅡ (AngⅡ), calcitonin gene-related peptide(cGRP) in essential hypertension (EH) and to investigate their clinical implications.Methods Immunoradiometric assay was used to measure the plasma peptides levels in 84 EHpatients, classified into three groups according to diastolic blood pressure, and 36normal subjucts. Results The levels of plasma ET, ANP, and AngⅡ in patients with mild,morderate, serious hypertension were significantly higher, but the plasma cGRP level waslower than those of controls. The levels of plasma ET, ANP and AngⅡ were positivelycorrelated with mean artery pressure (MAP) (r=0.4899, P<0.001;r=0.5786,P<0.001;r=0.3288,P<0.01), but the cGRP was not correlated with MAP(r=-0.06, P>0.05). Conclusion The plasma peptides may play an important role in EH.

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