【摘要】 目的 研究辛伐他汀对原发性高胆固醇血症患者血管内皮依赖性舒张功能的影响。方法 采用高分辨超声技术，对25例原发性高胆固醇血症患者降脂前后和25例血浆胆固醇水平正常的对照者的血管内皮依赖性舒张功能进行检测。结果 发现原发性高胆固醇血症组肱动脉血流介导性舒张较正常组明显减弱(3.5%±2.8%和14.5%±3.4%,P<0.001)，而二组对硝酸甘油的反应无显著性差异(20.5%±7.2%比22.9%±4.3%,P=0.49)。25例原发性高胆固醇血症患者服用辛伐他汀5～10mg治疗3.8±0.8月后，血浆总胆固醇从6.31±0.70mmol/L降至5.06±0.63mmol/L，同时肱动脉内皮依赖性舒张较治疗前明显改善(10.0±3.2%比3.5±2.8%，P<0.001)，而治疗前后肱动脉对硝酸甘油的反应无显著性改变。结论 原发性高胆固醇血症患者存在血管内皮依赖性舒张功能障碍；经辛伐他汀降胆固醇治疗后，受损的血管内皮依赖性舒张功能得到明显改善。

    Cholesterol-lowing therapy with simvastatin improves brachialendothelium-dependent relaxation Li jiang , ZhaoShuiping , Li Xiangping , et al. Department of Cardiology, Second Affiliated Hospital ,Hunan Medical University, Changsha 410011

     【Abstract 】 Objective To investigate theeffect of cholesterol-lowering therapy with simvastatin on endothelium-dependent relaxingfunction in patients with hypercholesterolemia. Methods With high-resolution ultrasound, we measured endothelium-dependentrelaxing function in 50 subjects: 25 of them with normal blood cholesterol and the otherswith established primary hypercholesterolemia.Results In patients with primary hypercholesterolemia, flow-mediateddilatation in arteries was much reduced comparied with control group (3.5%±2.8% vs 14.5%±3.4%,P<0.001). However, there was no significant difference in response to nitroglycerinbetween the two groups (20.5%±7.2% vs 22.9%±4.3%, P=0.49). Twenty-fivehypercholesterolemic patients were studied before and after cholesterol-lowering therapywith simvastatin (an inhibitor of HMG-CoA reductase) for 3.8±0.8 months, by which serumcholesterol lowered from 6.31±0.70 mmol/L to 5.06±0. 63 mmol/L (P<0.001).Flow-mediated vasodilations were greater after simvastatin therapy than before (10.0±3.2%vs 3.5±2. 8% ......