关键词:阿魏酸钠;再灌注损伤;丙二醛;超氧化物歧化酶;内皮素;一氧化氮
摘要 目的:观察阿魏酸钠对家兔心肌缺血再灌注损伤的保护效果。方法:16只兔随机分为非缺血对照组(A组)、缺血再灌注常规治疗组(B组)及缺血再灌注阿魏酸钠治疗组(C组)。结果:与B组比较,C组心肌组织MDA含量、血浆ET水平明显下降(P <0.01),心肌组织T-SOD活性及血清NO水平显著增高(P <0.01),心肌组织超微结构损伤程度明显减轻。结论:阿魏酸钠可明显减轻家兔心肌缺血再灌注损伤。
Influence of sodium ferulate on MDA,SOD,ET and NO during myocardial ischemia and reperfusion injury
Li Youqing,Zhang Jiansong,Cai Hongwei.Department of Anesthesiology,Xiangya Hospital,Hunan Medical University,Changsha 410008
Abstract Objective:To observe the protective effects of sodium ferulate (SF) on rabbit myocardial ischemia-reperfusion injury.Method:Sixteen rabbits were divided randomly into three groups:group A undergoing all procedures except for ischemia-reperfusion and treatment ......
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