关键词:高血压;睡眠呼吸暂停综合征;血压;昼夜节律
摘 要:目的 研究阻塞性睡眠呼吸暂停对高血压病患者血压昼夜节律的影响。方法 184例研究对象根据诊所血压、24小时动态血压和多导睡眠图监测结果分为正常对照组、高血压组、高血压病合并轻度或中重度睡眠呼吸暂停组。比较睡眠呼吸暂停指数、睡眠结构对血压昼夜节律的影响。结果 高血压病合并中重度睡眠呼吸暂停患者中,69.4%的昼夜血压曲线呈非勺型,其发生频率较其他各组显著增高,均有统计学显著性意义(P<0.001);III~IV期非快速动眼睡眠(NREM)和快速动眼睡眠(REM)时间占总睡眠时间的比率(为9.93%和12.56%)显著低于其他各组,呼吸暂停-低通气指数与III~IV期和REM期睡眠呈负相关(r=-0.299,P<0.01;r=-0.229, P<0.05)。结论 血压昼夜节律与呼吸暂停严重程度和睡眠结构破坏显著相关,非勺型血压曲线增加可能是睡眠呼吸暂停组患者心血管事件增加的重要危险因素。
Studyon circadian blood pressure variability in essential hypertensive patients withobstructive sleep apnea
ZHANG Jian HUI Rutai PEI Weidong, et al.
( Sino-German Lab forMolecular Medicine and Cardiovascular Molecular Medicine Center, Cardiovascular Instituteand Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037, China )
Abstract : Objective To demonstrate theinfluence of obstructive sleep apnea on circadian blood pressure variability in essentialhypertensive patients. Methods One hundred and eighty-four subjects were divided intohealthy control ......
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