徐 超 张绍东 崔 雯 朱 凌 100050 北京市神经外科研究所 中华神经外科杂志 1998 0 14 2


    关键词：脑缺血；纹体；γ-氨基丁酸；甘氨酸；蛋白激酶C 期刊 zhsjwkzz 0 论 著 fur -->


    

摘要 目的：研究蛋白激酶C抑制剂Chelerythrine对大鼠脑缺血时纹体γ-氨基丁酸(GABA)和甘氨酸(Gly)释放的影响。方法：用微透析和高压液相法测定大鼠半球缺血时纹体GABA和Gly的释放。结果：脑缺血时纹体GABA和Gly的释放明显升高。前者被Chelerythrine促进而后者则被抑制。结论：脑缺血时纹体GABA和Gly释放的明显升高参与了脑缺血病理过程，蛋白激酶C抑制剂Chelerythrine可能通过这一机制具有某些保护缺血大脑的作用。

The effects of PKC inhibitor chelerythrine on the releases of GABA and Gly from ischemic rat striatums

    Xu Chao， Zhang Shaodong， Cui Wen， et al. Beijing Neurosurgical Institute, Beijing 100050

    Abstract Objective: To study the effects of PKC inhibitor chelerythrine on the releases of GABA and Gly from ischemic rat striatums. Methods: The releases of GABA and Gly from rat striatums during global ischemia were determined by microdialysis and HPLC methods. Results: Release of GABA and Gly from ischemic rat striatums were significantly increased. The former was promoted, however, the latter was inhibited by PKC inhibitor Chelerythine respectively. Inclusion: Oncreased releases of GABA and Gly are involved in the pathogeneses of brain ischemia and the PKC inhibitor chelerythrine may have some protective effects on cerebral ischemia through this mechanism.

    Key words Brain ischemia Striatum GABA Gly PKC

不少研究证明蛋白激酶C(PKC)在神经细胞功能的调节中起关键作用 ......

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