关键词:异丙酚;预适应;心肌再灌注损伤
摘要 目的:研究异丙酚对快速起搏预适应的缺血心肌保护效应的影响。方法:24只白兔随机分成缺血对照,起搏缺血和异丙酚+起搏缺血组。结果:起搏组全心缺血30分钟再灌30分钟时左室收缩功能(LVDP、+dp/dtmax )及舒张功能(-dp/dtmax )的恢复明显优于缺血对照组(P<0.05),起搏期间给予异丙酚10μmol/L,使缺血后LV+dp/dtmax ,LVDP和LVEDP的恢复幅度显著差于起搏缺血组(P<0.05),且再灌注30分钟末LDH,CPK活性和ADP含量明显高于起搏缺血组,ATP含量则低于上述组。结论:异丙酚可缓解快速起搏即刻的心肌挛缩,但却消除其对缺血心肌的预适应效应。
Propofol eliminates the protective effect of heart pacing-induced preconditioning on the isolated ischemic myocardium Mao Weike,Yuan Shiying,Yao Shanglong.Department of Anesthesiology,Union Hospital,Tongji Medical University,Wuhan 430022
Abstract Objective:To study the effect of propofol on the protection of ischemic isolated heart preconditioned by rapid heart pacing.Method:24 white rabbits were assigned randomly into ischemia control(IC) ......
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