摘要 目的：了解脑膜瘤的临床、病理学特征与肿瘤增殖能力的关系。方法：对68例脑膜瘤标本进行流式细胞术(FCM)检测，分析几种临床病理特征与FCM的关系。结果：血管型、合体型脑膜瘤超二倍体率、DI和PI显著高于纤维型及混合型；重度水肿组DI、超二倍体率和PI显著高于中、轻及无水肿组；大肿瘤超二倍体率和DI均显著高于中、小肿瘤；复发性脑膜瘤的DI、PI均显著高于非复发组。结论：通过FCM分析可较准确地判定肿瘤的增殖能力，指导临床治疗。

Correlations betweenthe clinical and pathological features of meningioma and flow cytometry analysis Teng Liangzhu, Pu Peiyu, Li Feng, et al. Dept. of Neurosurgery, Shandong ProvincialHospital. Jinan 250021

     Abstract Objective: To study therelationship between the clinical and pathological features and the proliferative activityof meningioma. Method: The DNA ploidy and the cell kinetics in 68 samples of meningiomaswere examined by flow cytometry (FCM), with the relationship between some clinical andpathological features and FCM changes were analysed. Result: The percentage ofhyperdiploid cells, DNA Index(DI) and proliferative index(PI) were statistically higher inthe vascular and the syncytial subtypes of meningioma than those in the fibrous and mixedsubtypes, Also those in the severe edema group were higher than those in the moderate,mild and without peritumoral edema groups. The DNA hyperdiploidy were mostly found in thegroup of giant size tumor, DI and PI in the recurrent menigioma group were significantlyhigher than those in the nonrecurrent group. Conclusion: With FCM analysis, theproliferative activity of meningioma could be judged and the clinical measures could bedesigned.

     Key words Meningioma Pathology Flow cytometry

脑膜瘤是最常见的颅内良性肿瘤 ......