【摘要】 目的 探讨同种移植物对宿主免疫状态的影响以及排异反应对移植物的作用。方法 通过低温保存的大鼠同种异体带瓣主动脉和肺动脉异位移植的动物模型，观察同种移植后宿主体液和细胞免疫指标的变化，以及移植物的病理改变。结果 低温保存同种带瓣管道移植后有明显的免疫排异反应发生，细胞和体液免疫参与免疫排异反应的过程；慢性免疫排异反应以细胞免疫为主。结论 免疫排异反应导致移植血管内膜增厚、管壁钙化、狭窄和闭塞。

Study on immunological rejection in transplantation of cryopreservedaortic and pulmonary valved homograft LI Dongyu, ZHANG Renfu, DING Xiaomei,et al. Department of Cardiovascular Surgery, General Hospital of Shenyang MilitaryCommand, Shenyang 110015

    【Abstract】 Objective To investigate the influence of aortic andpulmonary homografts on host and the effect of immunological rejection on the homografts. Method Rat model of cryopreserved aortic and pulmonary valved homograft heterotopictransplantation was established to observe the changes of humoral and cellularimmunological response and pathological changes of implanted homografts. Result Obviousimmunological rejection occurred after implantation of aortic and pulmonary homografts.Cellular and humoral immunological responses were involved in the process of chronicimmunological rejection. Conclusion Immunological rejection resulted inintimal-thickening,calcification and obstruction of aortic and pulmonary homografts.

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