关键词：新月体肾炎；抗中性粒细胞胞浆抗体；抗肾小球基底膜抗体
【摘要】 目的 了解抗肾小球基底膜抗体(Anti-GBM)伴抗中性粒细胞胞浆抗体(ANCA)阳性患者的临床病理特点。方法 对我科近4年来68例Anti-GBM和(或)ANCA阳性患者进行Anti-GBM及ANCA检测，对其中4例两者均阳性患者进行临床病理分析。结果 68例患者中4例两者均阳性，占全部Anti-GBM阳性患者的24%，占全部ANCA阳性患者的7%。该4例患者Anti-GBM的百分结合率较单纯Anti-GBM阳性患者低。4例中3例髓过氧化物酶-ANCA(MPO-ANCA)阳性，1例蛋白酶3-ANCA(PR3-ANCA)阳性，全身系统表现较多，与单纯性ANCA阳性患者相似。所检病例肾脏病理多为新月体肾炎，免疫荧光检查多为IgG、C3 呈细颗粒样分布于GBM。虽经积极治疗，多数患者预后较差，类似单纯Anti-GBM肾炎。结论 Anti-GBM伴ANCA阳性患者全身表现类似单纯ANCA相关小血管炎患者，但治疗效果及预后相对较差又类似于Anti-GBM肾炎患者。
Anti-glomerularbasement membrane antibodies coexisting with anti-neutrophil cytoplasmicautoantibodies.Report of 4 cases and review of literatures
LIU Na,ZHAO Minghui,ZHANG Youkang,etal.Institute of Nephrology,First Hospital of Beijing Medical University,Beijing 100034
【Abstract】 Objective To studypatients with coexisting anti-glomerular basement membrane antibodies(Anti-GBM)andanti-neutrophil cytoplasmic autoantibodies(ANCA),and to analyze their clinical andpathological features.Methods 68sera from 68 patients with Anti-GBM and/or ANCA(MPO or PR3-ANCA)related diseases werecollected and were further tested for Anti-GBM and ANCA respectively.The clinical andpathological features of patients with coexisting Anti-GBM and ANCA were analyzed.Results
Of the 17 sera with Anti-GBM ......您现在查看是摘要页，全文长 14148 字符。