陈秋 严钟德 庞久高 重庆医科大学第二临床学院内分泌科 400010 中华肾脏病杂志 1999 0 15 4


    关键词：糖尿病；Ⅳ型胶原；肾功能 期刊 zhszbzz 0 论著 fur -->


    

【摘要】 目的 探讨Ⅱ型糖尿病患者血清Ⅳ型胶原(CⅣ)的变化及其与糖尿病肾损害可能的关系和作用。方法 采用放射免疫法对84例Ⅱ型糖尿病患者及45例正常人血清CⅣ水平进行检测。结果 糖尿病(DM)患者血清CⅣ水平[(105.48±18.09)μg/L]明显高于对照组[(89.20±9.70)μg/L，P<0.01]；微量及大量白蛋白尿期患者[(106.46±18.59)μg/L，(120.90±15.54)μg/L]较对照组显著增高(P<0.01，P<0.001)；DM各组间血清CⅣ水平差异显著，随着24 小时尿白蛋白排泄量(UAE)的增加及病程的延长，血清CⅣ水平递增，病程超过5 年者显著高于病程短于5年者；血清CⅣ与血尿素氮(BUN)、肌酐(Cr)、24 小 时UAE及尿N-乙酰-β-氨基葡萄糖苷酶(NAG)均呈显著正相关，与病程、空腹血糖(FBG)亦呈高度正相关。结论 DM存在着胶原代谢的异常。血清CⅣ水平随DN的严重程度而明显增高。血清CⅣ可作为DN早期诊断的敏感指标。

Clinicalsignificance of serum type Ⅳ collagen in the patients with diabetic nephropathy

CHEN Qiu, YAN Zhongde,PANG Jiugao. TheSecond Affiliated Hospital, Chongqing Medical University, Chongqing 400010

【Abstract】 Objective To studythe possible relationship between serum type Ⅳcollagen(CⅣ) and diabetic nephropathy(DN).Methods Serum CⅣ was determined byradioimmunoassay in 33 diabetic patients with normalbuminuria(A group), 32 cases ofmicroalbuminuria(B group), 19 cases of macroalbuminuria(C group) and 45 normal subjects ascontrol.Results The meanconcentration of CⅣ in total 84 diabeticpatients(105.48±18.09 μg/L) was higher than that ofcontrol(89.20±9.70 μg/L)(P<0.01), especially ingroup B(106.46±18.59 μg/L) and C(120.90±15.54 μg/L) was remarkablely higher as comparable withcontrol(P<0.01,P<0.001). There was significantly positive correlation between serumCⅣ level and diabetic duration,UAE ......