【摘要】 目的 了解缺血预适应和T₃ 对小肠缺血再灌注损伤的作用。方法 观察缺血预适应和T₃ 对大鼠小肠缺血再灌注后肠组织腺苷酸含量和肠粘膜损伤的影响。结果 T₃ 组和预适应组(预适应为10分钟缺血后15分钟再灌注)的小肠组织ATP及总腺苷酸含量均明显高于对照组(P<0.05)，肠粘膜损伤亦明显减轻；且T₃ 组比预适应组肠粘膜损伤更轻(P<0.05)，动物存活率增加(P<0.05)。结论 T₃ 和缺血预适应对小肠缺血再灌注损伤有一定保护作用，且T₃ 效果更佳。

Effects of ischemic preconditioning and triiodothyronine on small intestinal ischemia/reperfusion injury LIU Pengxi, LIU Qiang, LU Xinsheng, et al. Department of Surgery, Xiang Ya Hospital, Hunan Medical University, Changsha, 410008

     【Abstract】 Objective To assess the effects of ischemic preconditioning (IP) and triiodothyronine (T₃ ) on small intestinal ischemia/reperfusion injury. Method To observe the influence of IP and T₃ on rat small intestinal adenine nucleotide contents and mucosal lesion after ischemia/reperfusion.Results The small intestinal ATP and total adenine nucleotide contents of T₃ group and IP group were significantly increased as compared with those of control group (P<0.05), the intestinal mucosal lesion was also alleviated (P<0.01), and the mucosal lesion of T₃ group alleviated more than that of IP group (P<0.05), the survival rate of T₃ group was also increased as comparing with IP group. Conclusions T₃ and IP both have certain protective effect of small intestinal inchemia/reperfusion injury, and T₃ has a better effect than IP.

     ......