摘要 目的 ：探讨进一步提高慢性再生障碍性贫血(CAA)疗效的方法。方法：长效睾丸酮(TLD)单用(15例)及合用环孢霉素A(CsA)(30例)治疗CAA 45例。按全国统一标准评定疗效，并采用甲基纤维素培养法观察治疗前、后骨髓造血祖细胞水平的变化。结果：TLD+CsA组有效率

    为83.3%，高于单用TLD组的60.0%，且TLD+CsA组有效者骨髓造血祖细胞(BFU-E及CFU-GM)恢复

    明显优于单用TLD组有效者并更为迅速，两组间无效者骨髓BFU-E及CFU-GM水平无明显变化。

    结论：TLD+CsA治疗CAA疗效不仅高于单用TLD，且其有效者血液学恢复更为完全。

Treatment of chronic aplastic anemia with triolandren and cyclosporin A

    Shao Zonghong, Zheng Yizhou, Zhang Yizhi, et al. Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin, 300020

    Abstract Objective :To explore more effective regimen for chronic aplastic anemia (CAA). Methods :Forty-five cases of CAA were treated with triolandren (TLD) (15 cases) or TLD and cyclosporin A (CsA) (30 cases). Results: The response rate of TLD-CsA group (83.3%) was higher than that of TLD group(60.0%), furthermore, the recovery of bone marrow colony-forming cell (CFC) number of the responding patients was more complete and rapid in TLD-CsA group than in TLD group. Bone marrow CFC number had no significant change of all nonresponding patients in both groups. Conclusion:The response rate of TLD-CsA was higher than that of TLD alone, and the recovery of bone marrow CFC number of the responding patients was more complete and rapid in TLD-CsA group.

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