【摘要】 目的 观察磺脲类合并二甲双胍继发失效的2型糖尿病加用拜糖平的疗效。方法 将50例磺脲类与双胍类联合治疗继发失效的2型糖尿病人按非等量随机分组的原则分为拜糖平组(30例)和安慰剂组(20例)，治疗3个月，比较治疗。结果 拜糖平组患者的空腹和餐后1、2小时血糖明显下降，有效率为48.3%；安慰剂组治疗前后血糖维持不变，仅1例有效。结论 加用拜糖平可作为磺脲类与双胍类药物联合应用失效后的治疗方法之一。

    Efficacy of acarbose in the treatment of type 2 diabetes mellitus patients with secondary failure to combination of sulfonylurea and metformin Ning Guang,Wang Qinqin,Li Xian,et al.Diabetes Center,Ruijin Hospital,Shanghai 2nd Medical University,Shanghai,200025

    【Abstract】 Objective Studying the efficacy of acarbose in the treatment of type 2 diabetes mellitus patients with secondary failure to combination of sulfonylurea and metformin. Methods 50 type 2 diabetes mellitus patients with secondary failure to combination of sulfonylurea and metformin were divided randomly into 2 groups: acarbose group (n=30) and placebo group (n=20); 3 months later, the efficacy of acarbose was compared. Results The levels of fasting and 1-and 2-hour postprandial blood glucose decreased significantly in acarbose group with an effective rate of 48.3%, but remained unchanged except one in placebo group.Conclusion Acarbose is one of the choices in type 2 diabetes mellitus patients with secondary failure to combination of sulfonylurea and metformin.

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