【摘要】 目的 探讨肾移植前后外周血淋巴细胞选凝素-L 的表达水平变化与肾移植排斥反应的关系。 方法 应用单克隆抗体- 流式细胞仪荧光抗体技术监测33例肾移植受者外周血淋巴细胞选凝素-L的表达水平。 结果 肾移植术后所有患者选凝素-L表达水平较术前显著降低，排斥反 应时排斥组明显升高(49.1±13.8)，同期稳定组无明显变化(36.5±12.7)。 结论 选凝素-L与肾移植排斥反应密切相关，抑制选凝素-L表达是联合应用免疫 抑制剂防治排斥反应的重要作用机制，监测选凝素-L的表达水平有助于肾移植排斥反应的 诊断。

Detection of selectin-L in renal allograft recipients

BA I Han,PAN Guanghui,ZHENG Shaobin.

    (Department of Urology,Nanfang Hospital,Guan gzhou 510515,China)

【Abstract】 Objective To study the levels of select in-L in lymphocyte of renal transplant recipients. Methods The expression of selectin-L in lymphocyte was studied by means of flow cyt ometry in 33 renal transplant recipients 1 day before operation and on the 3rd, 6th,9th and 15th post operative days. Results The levels of selectin-L depressed notably after transplantation,ascended suddenly during the course of graft rejection. Conclusions Selectin-L is intimately correlated with renal transplant rejection.An important mechanism of the immunodepressives is the depress of selectin-L expression.The study of s electin-L is of help in the early diagnosis of graft rejection.

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