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关键词：肾肿瘤；癌；微卫星不稳定性
【摘要 】 目的 探讨微卫星不稳定性在肾细胞癌发生发展中的作用及其与临床病理指标的关系。 方法 应用PCR方法检测了34例新鲜肾细胞癌标本中不同染色体上的15个微卫星位点。 结果 34例肾癌中有15例(44%)表现为微卫星不稳定性，并多见于晚期肿瘤(Ⅲ～Ⅳ期)。 结论 微卫星不稳定性较广泛地存在于肾细胞癌中，可能与肿瘤发展相关。
Microsatellite instability in renal cellcarcinoma
TANG Dongqi, YU Lizhang，ZHANG Aimin，et al. Department of Urology, the First Hospital ,Institute of Urology, Beijing Medical University, Beijing 100034
【Abstract 】 Objective Todemonstrate whether microsatel lite instability is involved in the development of renalcell carcinoma and its relations to the clinicopathological parameters. Methods APCR based microsatellite instability assay was carried out using 15 microsat ellite locilocated on different chromosomes.Thirty-four freshly frozen samples were examined. Results Microsatelliteinstabil ities were recognized in 15 out of 34(44%) tumor specimens and were more commo nin advanced cancer (stage Ⅲ～Ⅳ).No relations were found among microsatellit einstability and other clinicopathological factors. Conclusions Microsatelliteinstability was importantly involved in human renal cell carcinoma and it might beassociated with the develo pment of this disease.
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