【摘要 】 目的 探讨癌基因MDM₂ 和抑癌基因p53在膀胱癌中的表达及其临床价值。 方法 采用免疫组织化学方法对23例膀胱癌标本进行检测。 结果 MDM₂ 、p53基因蛋白在肿瘤中阳性表达为39%和48%，与肿瘤分级分期，肿瘤复发性相关，两者异常表达呈负相关(r＝-0.2946,P<0 .05)。两者在癌旁组织中亦有一定表达率。 结论 MDM₂ 、p53基因的异常表达是膀胱癌中的基因事件，与膀胱癌发生发展密切相关，可作为临床判断肿瘤进展及可能预后的瘤标。

【Abstract 】 Objective Tostudy the expression of MDM₂ and p53 gene and their significance in humanbladder cancer. Methods Immunohistochemical technique was used tostudy the expression of MDM₂ and p53 gene in 23 cases of transitional cellbladder carcinoma and in th eir matched adjacent normal transitional epithelium. Results The positive expression rates of MDM₂ and p53 were 39% and 48% and werecorrelated with tumor grade,tumor stage and tumor relapse.MDM₂ was negativelycorrelated with p53 gene.Both MDM₂ and p53 had a certain expression rate in theepithelium adjacent to the tumor. Conclusions Aberrant MDM₂ and p53 are frequent genetic events in bladder cancer and might be closely correlated withtumorigenesis and/or tumor progression in urothelial neoplasm s.Aberrant MDM₂ and p53 phenotypes might serve as a marker of the progression and prognosis of bladdercancer and might provde a theoretical explanation for the easy relapse of transitionalcell carcinoma.

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