王金根 高解春 陈莲 高解春(200032 上海医科大学儿科医院外科)；陈莲(200032 上海医科大学儿科医院外科)；王金根(现在江西省人民医院泌尿外科) 中华泌尿外科杂志 2000 0 21 2


    关键词：肾母细胞瘤；肾源性剩余 期刊 zhmnwkzz 0 84-86 论著 fur -->


    

摘 要 ：目的 探讨肾母细胞瘤发生与胚胎肾分化发育及肾源性剩余的关系。方法 在光学显微镜下比较30例肾母细胞瘤和16例不同胎龄肾组织的形态特点；观察比较22例肾母细胞瘤瘤旁肾组织和30例非肿瘤成熟肾组织中肾源性剩余的阳性率。结果 肾母细胞瘤与早期胚胎肾在组织形态上有相似之处； 22例肾母细胞瘤瘤旁肾组织中6例见肾源性剩余存在，30例非肿瘤成熟肾组织中仅1例见肾源性剩余存在。结论 肾母细胞瘤的发生与胚胎肾分化停滞有关，肾源性剩余可能是肾母细胞瘤的前期病变。

Relationship of nephroblastoma to development of fetal kidney and to nephrogenic rest

WANG Jingen

    ( Department of Pediatric Surgery, Children's Hospital of Shanghai Medical University, Shanghai 200032,China)

    GAO Jiechun

    ( Department of Pediatric Surgery, Children's Hospital of Shanghai Medical University, Shanghai 200032,China)

    CHEN Lian

    ( Department of Pediatric Surgery, Children's Hospital of Shanghai Medical University, Shanghai 200032,China)

Abstract ： Objective To study the relationship of nephroblastoma to the differentiation and development of fetal kidney and to the existence of nephrogenic rest(NR).Methods 30 cases of nephroblastoma and 16 fetal kidneys were observed under microscope to compare their histomorphologic characters. 22 cases of renal tissues adjacent to nephroblastoma and 30 cases of non-neoplastic mature renal tissues were observed to compare the positive rate of NR.Results Histomorphology of nephroblastoma mimiced that of the immature structures in fetal kidney.NR was the locus immature structure existing in the mature kidney, similar to those in fetal kidney. NR was found in 6 of 22 cases of renal tissues adjacent to nephroblastoma whereas it was found in only 1 of the 30 cases of non-neoplastic mature renal tissues. The difference between these 2 groups was statistically significant.Conclusions The results suggested that the genesis of nephroblastoma is relevant to the retarded differentiation of fetal kidney. NR is the precursor lesion of nephroblastoma.

    Key words ： Nephroblastoma Nephrogenic rest▲

肾母细胞瘤是小儿最常见的肾脏肿瘤 ......