王涌泉 朱宝军 安瑞华 祁尤成 李长春 王涌泉 安瑞华 祁尤成 李长春 哈尔滨医科大学第一附属医院泌尿外科 150001；朱宝军 药剂科 中华泌尿外科杂志 1999 0 20 11


    关键词：尿石症；动物，实验；药物疗法 期刊 zhmnwkzz 0 论著 fur -->


    

【摘要】 目的 探讨广金钱草防石作用机制。方法 用金钱草注射液和提取液对草酸钙肾石模型大鼠进行抑制实验研究。结果 透射电镜显示金钱草能减轻肾小管细胞在乙二醇诱石过程中的崩解、坏死，肾小管腔内一些空泡状膜性囊和致密小体排入减少。注射液组肾组织中草酸和钙含量分别为(1.397±0.859)mg/g、(3.993±1.278)μmol/g，提取液组为(5.665±0.696) mg/g、(8.621 ±1.441)μmol/g，均明显低于成石组(P<0.05)。偏光镜观察显示注射液组和提取液组肾中草酸钙晶体形成程度比成石组明显减轻 结论 金钱草在体内能保护肾组织细胞，对草酸钙晶体形成有明显抑制作用，在防治尿石症方面可能有应用价值。

Inhibitory effect ofdesmodium styracifolium(Ds) injection on clacium oxalate renal stone formation

WANG Yongquan,ZHU Baojun,ANRuihua, et al

    Department of Urology, the First Affiliated Hospital,Haerbin Medical University, Haerbin150001

【 Abstract】 Objective To assess the mechanismof Ds in the prevention of stone-forming. Methods Ds-extract and Ds-injection preparation were administeredorally by gavage and intravenously to different groups of rats with calcium oxalate renalstone induced by 0.75% of ethylene glycol(EG). Results It was found that Ds could reduce the injurying changes offine renal structures caused by EG.Crystalization has been significantly less in theDs-injection group and the Ds-extract group as compared with the crystalization group. Thecontents of oxalate and calcium in renal tissue were also significantly reduced. Conclusions It was suggested that Ds would protect renal tubule cellsand inhibit calcium oxalate crystal formation effectively in vivo.Ds might be more usefulin preventing and treating urolithiasis if it were better concentrated and extracted.

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