膀胱肿瘤_癌_基因_膀胱移行细胞癌的微卫星不稳定性研究

膀胱移行细胞癌的微卫星不稳定性研究

http://www.100md.com 《中华泌尿外科杂志》 1999年第7期

膀胱肿瘤|癌|基因,关键词：

     邱建新唐孝达周佩军丁言德徐达张先有凌桂明吴国俊 200080 上海市第一人民医院泌尿科研究室(邱建新、唐孝达、周佩军、丁言德、徐达、张先有、凌桂明)；复旦大学遗传学研究所(吴国俊) 中华泌尿外科杂志 1999 0 20 7

    关键词：膀胱肿瘤；癌；基因期刊 zhmnwkzz 0 论著 fur -->

【摘要】目的 了解膀胱移行细胞癌(TCC)组织中微卫星不稳定(MSI)的情况及其与膀胱癌生物学行为的关系。方法选择4个阳性率较高的微卫星位点，应用PCR-MIA分析23例TCC病人的MSI及其与临床分期和病理分级的关系。结果 MSI在TCC患者中以扩增表达为主，23例TCC病人中有9例出现MSI，占39%，其中3例同时有2个位点出现MSI。病理分级和临床分期较高者，MSI的阳性率明显增高(P<0.025及P<0.005)。结论 TCC患者的肿瘤组织中存在MSI，且MSI预示着TCC的恶性程度较高。

Microsatelliteinstability in transitional cell carcinoma of the bladder

QIU Jianxin^,TANG Xiaoda,ZHOU Peijun,et al.

Department of Urology,Shanghai 1st People's Hospital,Shanghai 200080

【Abstract】 Objective Toevaluate the microsatellite instability (MSI) in transitional cell carcinoma (TCC) of thebladder and the relationship between MSI and the biological behavior of TCC. Methods 4microsatellite markers were selected to examine 23 TCC patients with PCR-MIA. Results MSI wasfound in 9 of 23 TCC patients (39.1%),all of them expressed expanding repeats,and 3 of theMSI patients also had 2 positive markers.Statistical analysis also found TCC patients withhigher G/T were more likely to have MSI (P<0.025 andP<0.005). Conclusions MSI mayplay some role in TCC,especially those with higher G/T.The presence of MSI denotes ahigher grade of malignancy.

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