陈焱 刘春晓 张积仁 陈焱 510602 广州，解放军第四五八医院泌尿外科；刘春晓 第一军医大学珠江医院泌尿外科；张积仁 肿瘤科 中华泌尿外科杂志 1999 0 20 2


    关键词：尿石症；茯苓；多糖 期刊 zhmnwkzz 0 论 著 fur -->


    

【摘要 】 目的 证实茯苓多糖的防石作用，比较茯苓多糖与消石素、五淋化石丹的防石作用。 方法 120只雄性 Wister成年大鼠分茯苓多糖、消石素、五淋化石丹和成石对照等 4组，每日喂以成石药乙二醇的同时，分别以茯苓多糖、消石素、五淋化石丹和自来水灌胃， 4周后处死取肾，常规病理切片，偏光镜下观察成石情况并摄影，比较各组照片上草酸钙结晶面积。 结果 茯苓多糖组、消石素组和五淋化石丹组肾内草酸钙结晶面积显著小于成石对照组，而茯苓多糖组结果较消石素组和五淋化石丹组更为显著。 结论 茯苓多糖能有效防止草酸钙结石的形成，其防石作用明显强于消石素，略强于五淋化石丹。

An experimental study onthe inhibiting effect of pachyman

    on lithiasis formation

CHEN yan,LIU Chunxiao,ZHANGJiren

Department of Urology,458thHospital,Guangzhou 510602

【 Abstract 】 Objective To elucidate the inhibitingeffect of pachyman on lithiasis formation and to compare its lithagogue effect with Uralytand Wulin Hushi Dan. Methods 120 Wister male adult rats were divided into 4 groups,the pachymangroup,the Uralyt group,the Wulin Hushi Dan group and the control group.Stone formationdrugs were fed to the rats daily and in the meantime pachyman,Uralyt or Wulin Hushi Danwas fed to the corresponding group of rats and water to the controls instead.4 weekslater,the rats were sacrificed and the kidneys were removed and made into sections whichwere studied under polarized microscope for stone formation. Results Areas of calcium oxalate crystal in the kidneys ofpachyman group were significantly smaller than those in the other 3 groups,and so was theUralyt and Wulin Hushi Dan group as compared with the controls. Conclusions Pachyman does inhibit the formation of urinaryllithiasisand the effect is stronger than either Uralyt or Wulin Hushi Dan.

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