关键词：膀胱肿瘤；癌；凝集素；树突细胞
摘要 为探讨凝集素染色与树突细胞(DC)的关系，在膀胱癌发生、发展过程中的作用，选取二种凝集素和抗S-100蛋白抗体，对87例膀胱癌进行免疫组化(ABC法)染色。结果显示：肿瘤的病理分级与ConA和WGA的强表达呈正相关，与DC的数量呈负相关(P<0.005)；膀胱癌复发组ConA和WGA的强阳性率在80.0%以上，而DC的强阳性率仅5.4%，有显著性差异(P<0.005)；术后生存<5年病例的ConA和WGA强阳性率高于94.0%，而DC数量则显著减少(P<0.001)。提示DC的减少或消失，破坏了机体局部免疫监视系统，导致膀胱癌的发生，认为DC、ConA、WGA是判断膀胱癌分级及预后有价值的标记物。
Dentritic cell and expression ofagglutinin in bladder cancer Zou Guihua,Xiong Huaqi, Peng Ruiyuan, et al. Teaching and Research Section of Pathology, JiangxiMedical College, Nanchang 330006
Abstract Dentritic cell (DC) and expression of agglutinin were studied in 87cases of transitional cell bladder carcinoma by immunohistochemistry using 4 kinds ofbio-agglutinin and anti-S-100 protein antibodies. The result showed that tumorpathological grade was positively correlated with the strong expression of ConA and WGAand negatively with the quantity of DC (P<0.005).Strongexpression of ConA and WGA was observed in more than 80.0% of recurrent cases with only5.4% of DC strong staining. In cases whose survival time was less than 5 years afteroperation, the strong positive rate of ConA and WGA reached more than 94.7% and thequantity of DC decreased markedly (P<0.001). It wassuggested that the reduce or disappear of DC would damage human local immunologicalsurveillance system and correlated with the development of bladder carcinoma. DC, ConA andWGA were believed to be useful markers in identifying bladder cancer grade and theprognosis of the patients.
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