王为服 张元芳 丁 强 徐一甄 凌治萍 王为服 570311 海口 海南省人民医院泌尿外科；张元芳 丁 强 上海医科大学华山医院泌尿外科；徐一甄 糖尿病室；凌治萍 上海医科大学电镜室 中华泌尿外科杂志 1999 0 20 10


    关键词：糖尿病；阳萎 期刊 zhmnwkzz 0 论著 fur -->


    

摘要 目的 探讨糖尿病(DM)性阴茎勃起功能障碍(ED)的发病机理。 方法 SD大鼠注射链脲佐菌素制造DM动物模型后，注射阿朴吗啡观察6周、8周及12周大鼠阴茎勃起情况，筛选DM性ED大鼠模型，观察其阴茎海绵体组织超微结构的改变。 结果 DM性ED大鼠模型阴茎海绵体内皮细胞及平滑肌细胞超微结构均有明显的病理改变：线粒体退变、内质网扩张，糖原颗粒、吞饮小泡及微丝减少。此外，还可见大量间质组织增生及微血管腔闭塞。随DM病程不同，其改变程度不同，8周时以内皮细胞损害为明显，12周时以平滑肌细胞损害为明显。 结论 DM严重影响阴茎勃起功能，海绵体组织超微结构的病理改变可能是DM性ED发病机理之一。

Ultrastructual studies ofcavernous tissue in impotent rats with diabetes mellitus

WANG Weifu^* ,ZHANG Yuanfang,DING Qiang,et al.^*

    Department of Urology,Hainan Provincial People's Hospital,Haikou 570311

Abstract Objective To study theultrastructure of cavernous tissue in impotent rats with diabetes mellitus (DM). Methods Sprague-Dewleyrats were injected intraperitoneally with streptozotocin(STZ) to make experimental modelsof DM.Injected with apomorphine,penile erections in rats with DM and in controls wereobserved and noted on the sixth week,the eighth week and the twelfth week from the fourthday of injecting STZ.The experimental models of impotent rats with DM were then selectedand the ultrastructure of the cavernous tissues studied. Results The significantpathological changes were observed in the endothelial and smooth muscle cells of cavernoustissue of impotent rats with DM:these were the degeneration of mitochondria,the dilatationof endoplasmic reticulum,the reduce of glycogen particle,pinocytotic vesicle andmicrofilament.The proliferation of messenchymal tissue and obturation of microvessel werealso observed.The change extent of cavernous tissue was positively correlated with theduration of DM,the changes of endothelial and smooth muscle cells being obvious on theeight or twelve week. Conclusions The function of penile erection is affectedseriously by DM,and these pathological changes of cavernous tissue may be one of the mostimportant mechanisms of impotence with DM.

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