摘要 为了提高膀胱癌的治疗效果，采用BCG-CWS(细胞壁骨架)行膀胱内灌注，防治浅表膀胱癌复发。53例膀胱癌患者手术后分为BCG-CWS组和BCG组。BCG-CWS组(25例)5mgBCG-CWS加无菌生理盐水50ml注入膀胱，BCG组(28例)75mg BCG加生理盐水50ml注入膀胱。每周1次，连续6周，以后每月一次连续两年。随访6～32个月，中位数26个月。两组比较肿瘤复发率无显著性差异，BCG-CWS组毒副反应比BCG组明显减少。结论：BCG-CWS能有效地防治浅表膀胱癌复发，毒副反应低，并具有保存期长，使用方便的特点。

Experience with intravesical BCG-CWStherapy for superficial bladder tumors DaiYuping,Mei Hua,Ouyang Yingmin,et al.Department of Urology,the First AffiliatedHospital,Sun Yatsen University of Medical Sciences,Guangzhou 510080

    Abstract BCG-CWS has been used in clinical study for preventing therecurrence of superficial transitional cell carcinoma.53 patients were randomized into twogroups:BCG-CWS group and BCG group.The protocol of immunoprophylaxis included 6 weeklyinstillation of 5mg BCG-CWS in 50ml normal saline via a catheter.Immunotherapy was givenonce monthly for at least two years.Results:Followup (from 6 to 32 months with a median26.3 months) consisted of cystoscopy and cytology with cold cup biopsies carried out every3 months for 2 years.It showed that in three patients (12.0%) recurrence occumed after theinstillation of BCG-CWS.During the instillation the rate of toxic side effects was verylow.The intravesical BCG-CWS appears to be an effective prophylaxis against recurrence.Itis supperior to BCG vaccine with fewer complication,but with similar effective rate (P>0.05).Long-term result needs further investigation.BCG-CWS can bepreserved even longer without changing its antitumor property and is easily available forrural hospitals.

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