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关键词：哮喘；呋塞米；呼吸功能试验；T淋巴细胞亚群
摘要 目的 评价呋塞米(速尿)吸入对老年人慢性哮喘的治疗效果。 方法 72例老年慢性哮喘患者分别给予速尿(A组)、速尿+溴化异丙托品(B组)和溴化异丙托品(C组)治疗，每组各24例，并与60例非老年慢性哮喘患者的结果进行比较。吸入前后测肺功能〔最大肺活量(FVC)、一秒钟最大呼气量(FEV1 )、最大呼气流速(PEFR)〕和外周血T细胞亚群。 结果 老年组总有效率(有效+显效)，A、B、C组分别为75%、92%、67%。肺功能和T细胞亚群改变：A组FEV1和CD4吸入前后变化差异有显著性(P<0.05)；B组肺功能指标和CD4、CD8、CD4/CD8差异有非常显著性(P<0.01或0.001)；C组除PEFR有显著变化(P<0.05)外，余项也有改善，但无统计学意义。非老年组的疗效与老年组疗效基本相同。 结论 速尿吸入对老年人慢性哮喘有防治作用，特别是速尿+溴化异丙托品联合吸入效果更好。
Effect ofinhaled furosemide on pulmonary function and T lymphocytesubsets in peripheral blood in aged patients with chronic asthma
Che Hongzhu, ShanZhaoyun, Luo Kaili. Shenyang Hospital of Air Force, PLA, Shenyang 110042
Abstract Objective Toassess the effect of treatment with inhaled furosemide on aged patients with chronicasthma. Methods Seventy-two aged patients with chronic asthma were divided into 3groups of 24. Patients in Group A, B and C were given furosemide, furosemide plusinpratropin bromide, and inpratropin bromide, respectively, by in haling. Sixty non-agedpatients with chronic asthma treated similarly were controls. Both before and afterinhaling, pulmonary function and T lymphocyte subsets in peripheral blood were measured. Results Thetotal effective rates of treatment in group A, B and C were 75%, 92% and 67%,respectively. After inhaling, the changes of FEV1 and CD4 were obvious (P<0.05) in group A, and FVC, FEV1 , PEFR and CD4, CD8, andCD4/CD8 ratio were markedly changed in group B. Conclusions Inhaled furosemide can prevent and treat chronic asthma. Theeffect of inhaled furosemide plus inpratropin bromide is better than that of furosemide orinpratropin bromide alone.
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