【摘要】 目的 对狂犬病疫苗是否应该含有铝佐剂进行实验研究。方法 通过检测疫苗抗体、效力(ED₅₀ )及建立符合狂犬病现场实际的动物模型比较含铝佐剂和不含铝佐剂疫苗防治狂犬病的效果。结果 免疫后第4天和第7天抗体滴度铝佐剂疫苗组明显低于不含铝佐剂疫苗组；在NIH效力测定中，铝佐剂疫苗组的ED₅₀ 为93-132 ng较疫苗组ED₅₀ 221 ng少用抗原量一半左右，但该效力测定法不符合狂犬病现场实际；在符合现场实际的动物模型中，铝佐剂对狂犬病疫苗没有任何促进作用。结论 在实验狂犬病中，铝佐剂不促进狂犬病疫苗防治狂犬病，而且有不利影响。

Influence of aluminum adjuvant to experimental rabies vaccine LIN Haixiang, Perrin P. National Institute for the Control of Pharmaceutical and Biololgical Products, Beijing 100050

    【Abstract】 Objective To study whether the rabies vaccine for human use should contain aluminum adjuvant.Methods Testing vaccine antibodies and efficacy(ED₅₀ ), comparing the effect between aluminum adjuvant contained and non-aluminum adjuvant contained vaccines in a new animal model which accords with the rabies field practice.Results At fourth and seventh day after immunization, the neutralizing antibody titres of the rabies vaccine containing aluminium adjuvant were much lower than that of the vaccine not containing aluminum adjuvant. In the NIH efficacy test the ED₅₀ of the vaccine containing aluminum adjuvant was 93-132 ng while the ED₅₀ of the vaccine not containing aluminum adjuvant was 221 ng, but the NIH test does not accord with the rabies field practice. In that new animal model, aluminum adjuvant to rabies vaccine had not any promoting effect for preventing and treating rabies.Conclusion Aluminum adjuvant to rabies vaccine has no advantages, this paper suggests that the vaccines containing and not-containing aluminium adjuvant had better compare in human bodies. If the results are the same as our experiments, the aluminum adjuvant should be eliminated from rabies vaccine for human use.

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