广东省登革热病原学和血清学检测
登革热,流行病学|登革热病毒|蚊|抗体，病毒,关键词：
关键词：登革热/流行病学；登革热病毒；蚊；抗体，病毒
【摘要】 目的 了解1978～1995年广东省多次发生登革热Ⅰ～Ⅳ型流行的病原学。方法 在流行区捕捉9种蚊媒，进行病毒分离。结果 阳性率白纹伊蚊为20.69%，埃及伊蚊为18.95%，致乏库蚊为10.29%，其余6种蚊媒为阴性。这三种蚊媒间的病毒分离阳性率无显著性差异(χ2 =2.77,P>0.05)。在海南岛和湛江地区，埃及伊蚊是主要的传播媒介，其他的流行区是白纹伊蚊。患者发病3天内病毒分离的阳性率在73.58%～82.05%之间，发病第8天仍可分离到病毒 。患者双相血清检测抗体的阳性率最高为93.89%，最低为33.71%；发病第5天后可检测到1gM抗体，最长可维持至病后第33天。结论 发病1～4天可采血进行病毒分离，5天后可检测IgM抗体，进行早期快速诊断。
An etiological and serological study on Dengue epidemic in Guangdong Province Wen Jianhua,Liang Fengping,Du Fu,et al.Institute of Epidemic Prevention of Guangdong Province, Guangzhou 510300
Abstract In 1978-1995,Dengue fever epidemics(serotype 1-4)occured in Guangdong Province. Among 9 species of mosquitoes found in the epidemic areas,the positive rate of virus isolation in Aedes albopictus was 20.69%,in Aedes aegypti 18.95%,in Culex quinquefasciatus 10.29%, Dengue viruses were not isolated in other 6 species of mosquitoes.The positive rate of virus isolation in the three species showed no significant differences (χ2 =2.77 P>0.05). Aedes aegypti was the main transmitting vector in Hainan Island and Zhanjiang District, whereas Aedes albopictus was in the other epidemic areas.The positive rate of virus isolation within 3 days of disease onset was between 73.58% and 82.05%,but the virus could still be isolated on the 8th day of disease onset. The highest antibody positive rate from the patients' paired-sera was 93.89% and the lowest was 33.71%.IgM antibody could be detected 5 days after the disease onset in some cases, even on the 33th day of disease onset. These results suggest that virus isolation by collecting patient's blood within 1-4 days of disease onset, or IgM antibody detection after 5days of disease onset can be used as method for early and rapid diagnosis of the disease.
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