赵和平 程宝珠 郭慧安 张天生 张玲荣 王勤英 030001 太原 山西医科大学第一医院(赵和平 郭慧安 张玲荣 王勤英)；太原市商业职工医院(程宝珠)；铁十二局医院(张天生) 中华实验和临床病毒学杂志 1998 0 0 1


    关键词：肝炎病毒，丙型；基因型；限制性内切片段长度多态性；干扰素 期刊 zhsyhlcbdxzz 0 论著 fur -->


    

【摘要】 目的 为了解山西省丙型肝炎病毒的基因型和基因型对干扰素疗效的预示价值。方法 用HCV5’NC区酶切分型方法对94例丙型肝炎病人进行基因分型，并观察其中45例患者对干扰素α-1b治疗的应答。结果 显示HCV Ⅰ组(Ⅰ、Ⅱ型)感染80例(85.1%)，HCV Ⅱ组(Ⅲ、Ⅳ型)感染12例(12.8%)，HCV Ⅰ/Ⅱ组混合感染2例(2.1%)。在接受干扰素治疗的病例中，HCV Ⅰ组感染(35例)的应答率为37.1%，持续应答率为17.1%，而Ⅱ组感染(10例)的应答率为80%，持续应答率为60%，两组相比，有显著性差异(P<0.05，P<0.025)。结论 表明山西省以HCV Ⅰ组感染为主，干扰素对HCV Ⅱ组感染的疗效优于HCV Ⅰ组感染，HCV基因型有预测干扰素疗效的意义。

Genotypic analysis of hepatitis C viruses and its significance in interferon treatment

Zhao Heping, Cheng Baozhu, Guo Huian, et al. The First Affilicated Hospital of Shanxi University of Medical Sciences, Taiyuan 030001

Abstract To study the genotypes of HCV infection in Shanxi Province and the response of HCV genotypes to interferon therapy, the genotypes of HCV were analysed by restriction fragment length polymorphism in 94 chronic hepatitis C patients who were positive for HCV RNA (RT-PCR). It was shown that 80 patients (85.1%) were group Ⅰ infection, 12 (12.8%) were group Ⅱ infection and 2 (2.1%) were group Ⅰ/Ⅱ co-infection. 45 chronic hepatitis C patients with different genotypes (35 with HCV group Ⅰ, 10 with group Ⅱ) receirved rIFN α-1b 3MU three times a week for 6 months and were followed up to 12-34months. The responsive rate was significantly higher in patients with group Ⅱ infection (80%) than that in patients infected with group Ⅰ (37.1%) (P<0.05). Sustained response was observed in 60% for group Ⅱ and in 17.1% for group Ⅰ(P<0.025). The date indicated that HCV group Ⅰ is the major type of HCV infection in Shanxi Province the and HCV genotype seems to be an important factor in determining the response rate to IFN treatment in patients with chronic hepatitis C.

     ......

您现在查看是摘要页，全文长 15289 字符。