【摘要】 目的 研究血小板衍生生长因子在病毒性肝炎肝纤维化中的作用。方法 以免疫组化技术检测血小板衍生生长因子(PDGF)-BB以及PDGF的β受体(PDGFR-β)在病毒性肝炎肝组织中的表达。结果 PDGF-BB及PDGFR-β在肝组织中的表达与肝纤维化程度明显相关，肝硬变及慢性肝炎S3～4期患者肝组织PDGF-BB及PDGFR-β表达强度明显高于急性肝炎及慢性肝炎S0～2期患者，同时与结蛋白、Ⅲ型前胶原肽在肝组织中的表达以及血清金属蛋白酶组织抑制因子-1(TIMP-1)呈明显正相关。结论 PDGF-BB及PDGFR-β不仅对星状细胞的活化、分裂、增殖及其合成胶原等细胞外基质(ECM)均有明显的促进作用，而且可能通过上调TIMP-1减少ECM的降解，促进肝纤维化的发生和进展过程。

Abstract The expression of platelet-derived growth factor(PDGF)-BB and PDGF receptor-β(PDGFR-β)in liver tissues from viral hepatitis was detected by immunohistochemistry.The results showed that the expression of PDGF-BB and PDGFR-β in the liver tissues correlated closely with the degree of liver fibrosis. The levels of their expression in the liver cirrhosis and fibrosis stage S3～4 of chronic viral hepatitis(CH)were much higher than those in acute viral hepatitis and fibrosis stage S0～2 of CH.Meanwhile,the expression of PDGF and its receptor was associated with the expression of desmin-positive cells pro-collagen Ⅲ peptide in liver tissues and tissue inhibitor of metalloprotenase-l in serum. It is suggested that PDGF-BB and its receptor-β may promote the progress of liver fibrosis by means of the activation,proliferation and differentiation of satellite cells.

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