摘要 目的 了解老年收缩期高血压(OSH)患者血浆神经肽Y(NPY)浓度的变化及培哚普利对血浆NPY浓度的影响。 方法 对OSH患者44例(Ⅰ、Ⅱ、Ⅲ期分别为15、13、16例)应用放免法测定培哚普利治疗前后血浆NPY浓度变化，并与健康老年人作对照。结果 OSH患者血浆NPY水平(33.68±7.41pmol/L)较健康对照组(17.37±5.08pmol/L)显著增高，且NPY的水平与收缩压增高的幅度呈正相关；心脏损害越严重，NPY的水平越高。培哚普利使OSH患者NPY浓度明显下降，且下降幅度

    与血压降低幅度呈正相关。 结论 在培哚普利的降压作用中，有NPY水平下降这一因素参与，早期应用培哚普利可能对改善OSH患者预后有一定影响

A study on changes of plasma neuropeptide Y in elderly with systolic hypertension and afterperindopril treatment Zeng Chunyu, Liu Guangyao, Wang Xukai, et al.Cardiology Department, the Third Affiliated Hospital of the Third Military Medical University, Chongqing 400042

Abstract Objective To investigate the changes of plasma neuropeptide Y(NPY) levels in elderly patients with systolic hypertensionbefore and after perindopril treatment.Methods There were 44 patients of Ⅰ (15 cases), Ⅱ (13 cases) andⅢ (16 caese) stages of systolic hypertension, NPY levels were determined by radioimmunoassay. Results 1.Theaverage NPY levels in elder patients with systolic hypertension (33.68± 7.41pmol/L)weresignificantlyhigher than that in the control group (17.37± 5.08pmol/L;P< 0.05).2.The NPYlevels were positively correlated with systolic blood pressure (r=0.31 ......