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关键词：糖尿病，非胰岛素依赖型；冠状动脉疾病；纤溶酶原灭活剂
摘要 目的 从分子遗传水平进行基因多态性研究，以探讨2型糖尿病易伴发冠心病的内在原因。 方法 对81例2型糖尿病患者、93例非糖尿病(非DM)患者进行口服糖耐量试验、血脂分析、血浆纤溶酶原激活物抑制因子(PAI-1)基因多态性分析。 结果 2型糖尿病和非DM相比PAI-1基因启动子4G频率明显增加(42%和 31%，P<0.001)；2型糖尿病伴冠心病与不伴冠心病相比，PAI-1基因启动子4G频率及4G/4G基因型频率存在明显差异(52%和 30%,32% 和 14%;P分别<0.001、0.05)；非2型糖尿病伴冠心病与不伴冠心病相比，PAI-1基因启动子4G频率及4G/4G基因型频率则无明显差异(31%和 31%,8% 和 16%,均为P>0.05)。 结论 PAI-1基因4G等位基因可能是糖尿病合并冠心病的内在危险因素。
Therelationship between polymorphism of PAI-1 gene and type 2 diabetes mellitus associatedwith coronary heart disease
Ding Guoxian, ShenJie, Chen Jiawei. First Affiliated Hospital, Nanjing Medical University, Nanjing 210029
Abstract Objective Toexplore the association of type 2 diabetes with coronary heart disease (CHD), from genepolymorphism analysis. Methods The polymorphism of plasminogen activator inhibitor-1 (PAI-1) genewas analyzed by PCR technique in 81 elderly with type 2 diabetes and 93 non-diabeticelderly. Results The frequency of PAI-1 4G in type 2 diabetics was significantlyincreased than in non-diabetics (42% vs 31%, P<0.001).The frequency of 4G/4G genotype and 4G allele frequency of PAI-1 gene were increased intype 2 diabetic patients with CHD in comparison with type 2 diabetes without CHD (32% vs14%, 52% vs 30%, P<0.05 ......
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