【摘要】 目的 通过大鼠脑冲击伤模型,观察脑损伤后兴奋性氨基酸谷氨酸变化规律以及拉莫三嗪对急性脑水肿的治疗效果,并探讨其作用机制。方法 采用干湿重法,微透析技术及氨基酸分析测定脑损伤后不同区域,不同时相脑组织的水含量及谷氨酸的浓度。结果 (1)脑损伤组脑组织的水含量,细胞外液谷氨酸浓度明显高于对照组;(2)脑损伤组损伤区域的脑水肿和细胞外液谷氨酸呈自身扩播性;(3)拉莫三嗪治疗组脑组织含水量以及谷氨酸浓度明显低于脑损伤非治疗组。结论 拉莫三嗪通过抑制神经细胞释放谷氨酸而发挥对脑水肿的治疗作用。

Effect of Lamotrigine on Cerebral Edema Following Traumatic Brain Injury in Rats CHENG Yuan, CHEN Fu-ren, WU Yong, et al. Dept. of Neurosurgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400042

    【Abstract】 Aim To investigate the effect of lamotrigine (LTG) on cerebral edema following traumatic brain injury, and to discuss the mechanism. Methods This study was done on the experimental animal models (rats) with impacted brain injury. The change of water content in brain was measured with “drying-wet” method, and the change of glutamate was measured with microdialysis technique and amino acids automaticanalyzes. Results (1) The water content and glutamate in the injured brain were significantly greater than those in the control group. (2) In the injured brain, the contents of water and glutamate showed a self-diffusion process. (3) The contents of water and glutamate in the LTG-treated group were significantly lower than those in the nontreated group. Conclusion LTG can deal with cerebral edema by inhibiting neurons to release glutamate.

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