刘久敏 李立人 唐安戊 陈凤莲 梁敏文 许建宁 卢百灵 510080 广州市，广东省人民医院泌尿外科(刘久敏、许建宁)，核医学科(李立人、唐安戊、陈凤莲、卢百灵)，检验科(梁敏文) 中华老年医学杂志 1998 10 17 5


    关键词：前列腺肿瘤；甲状旁腺相关蛋白；前列腺特异抗原 期刊 zhlnyxzz 0 临床研究 fur -->


    

摘要 目的 观察前列腺癌患者血清甲状旁腺相关蛋白(PTHrP)与病情及前列腺特异抗原(PSA)的关系。 方法 采用免疫放射法(IRMA)和放射免疫法(RIA)测定31例前列腺癌患者血清PTHrP、PSA和钙离子，并以50例前列腺增生症(BPH)、55例健康人和57例其它恶性肿瘤患者作对照。 结果 前列腺癌组血清PTHrP(4.6±4.4pmol/L)和PSA(80.0±52.6μg/L)明显高于BPH和健康组(均为P<0.01)。31例前列腺癌患者中13例(41.6%)血清PTHrP增高，这13例均属D期，其血清PTHrP水平明显高于A期(P<0.01)。21例前列腺癌伴发高钙血症(HHM)者血清PTHrP与PSA呈正相关关系(r=0.823，P<0.001)。BPH组无1例血清PTHrP增高。 结论 血清PTHrP与前列腺癌的病程进展有关，其含量增高表明肿瘤已属晚期。

The significance of determination of serum parathyroid hormone-related protein in prostatic cancer

Liu Jiumin, Li Liren, Tang Anwu, et al. Department of Urology, Guangdong Provincial People's Hospital, Guangzhou510080

Abstract Objective To assess the value of parathyroid hormone-related protein (PTHrP) as a tumor activity marker in prostatic cancer (PCa). Methods Serum PTHrP, PSA and Ca²⁺ were determined by radioimmunoassay in 31 cases of PCa,50 cases of benign prostatic hyperplasia (BPH), 57 other malignancies and 55 healthy subjects. Results The mean levels of serum PTHrP and PSA in PCa (4.6±4.4pmol/L and 80.0±52.6μg/L)were significantly higher than those in BPH and healthy subjects. The serum PTHrP levels in 13 cases of PCa of stage D were higher than those of stage A(P<0.01). PTHrP and PSA were strongly correlated (r=0.823,P<0.001) in 21 cases of PCa with hypercalcemia. None of BPH patients had elevated in serum PTHrP. Conclusions Serum PTHrP is helpful in the assessment of the development of PCa. The elevated level of serum PTHrP indicates a late stage of cancer.

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