【摘要】 目的 探讨急性弥漫性脑肿胀的发病机制。方法 电解毁损家兔下丘脑背内侧核、中脑网状结构和延髓网状结构,观察脑血流量和颅内压的变化。结果 单独毁损引起短暂可逆性脑血流量增加和颅内压增高,联合毁损引起持续不可逆性颅内压增高,脑血流量超早期增加和早期减少,以及早期形成脑水肿。结论 大脑血管紧张性调节中枢广泛存在于下丘脑、中脑和延髓,其结构或功能的破坏是急性弥漫性脑肿胀形成的根本基础。

Experimental Study on Pathogenesis of Acute Diffuse Brain Swelling WU Si-rong, HUI Guo-zhen, YIN Qi-zhang. Dept. of Neurosurgery, First Affiliated Hospital, Suzhou Medical College, Suzhou 215006

    【Abstract】 Aim To investigate the pathological mechanism of acute diffuse brain swelling. Methods Cerebral blood flow (CBF) and intracranial pressure (ICP) were measured after electrolytical destruction of the dorsomedial nucleus of the hypothalamus, the midbrain reticular formation, or/and the reticular formation of the medulla oblongata. Results Transient and reversible increases in CBF and ICP were found after respective destruction of these areas; while a progressive and irreversible increase in ICP, a superearly increase and an early reduction in CBF as well as early brain edema were found after simultaneous destruction of them. Conclusion There exist vasomotor centers in the hypothalamus, the midbrain and the medulla oblongata, and the destruction of these centers is the basic reason for acute diffuse brain swelling.

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