张信红 钟光林 裴保香 刘屏 100853 北京，解放军总医院 中华流行病学杂志 1999 0 0 6


    关键词：头孢哌酮；药物经济学；药代动力学 期刊 zhlxbxzz 0 论著 fur -->


    

【摘要】 目的 对国产与进口头孢哌酮进行药物经济研究。方法 高效液相色谱法测定两药的人体药代动力学参数，临床观察两药治疗肺部感染患者的疗效、细菌清除、药物不良反应及治疗费用。应用成本-效果分析法分析成本效果比。结果 两药的体内药代动力学过程基本一致，临床有效率、细菌清除和不良反应的差异不明显，两药的成本效果比及治疗费用差别显著。结论 国产头孢哌酮的作用与进口头孢哌酮无明显差异，但在成本和价格上有显著优势。

    

Study on thepharmacoeconomics between imported and domestic cefoperazone

ZHANG Xinhong, ZHONG Guanglin, PEI Baoxiang, et al.

The Department of Pharmacy , 301Hospital， Beijing100853

【 Abstract】 Objective By evaluating the pharmacokinetics and clinical therapeuticeffectiveness, ADRs and clinical expenses, both Imported and Domestic Cefoperazone werecompared. Methods Clinical therapeutic effectiveness, abnormal drugreaction (ADR) and clinical expenses of imported Cefoperazone were compared with that ofdomestic product. Both of the two drugs' pharmacokinetics were also studied by HPLC. Result Both products did notshow significant differences in pharmacokinetics, therapeutic effectiveness andbactericidal power. However, the domestic product had more ADR than the imported ones andthe clinical expenses of domestic Cefoperazone was significantly lower than the importedones. Conclusion It is a safe, rational, economic choice to replace the importedCefoperazone with the domestic product.

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