关键词：病毒性肝炎；传播途径；流行因素；献血浆；家庭聚集性
【摘要 】 目的 了解某农村人群甲、乙、丙、戊和庚型肝炎病毒的感染状况及其流行特点。方法 应用酶联免疫试验(EIA)检测血清抗-HAV、HBsAg、抗-HBs、抗-HBc、抗-HCV、抗-HEV和抗-HGV，并对抗-HGV阳性者应用套式逆转录聚合酶链反应法(RT-nPCR)检测HGVRNA。结果 该人群抗-HAV、抗-HCV、抗-HEV和抗-HGV流行率分别为86.9%、11.5%、2.9%和1.8%，HBsAg阳性率为8.0%，HBV总感染率为54.8%。HAV以5岁以下儿童感染率最低(35.0%)，到10岁时85.0%的儿童已感染HAV。HBsAg阳性率呈现两个高峰，分别在5～9岁和40～49岁年龄组；HBV总感染率到10岁时为55.0%，然后随年龄增长而上升。HCV感染主要集中在20～49岁年龄组(占77.8%)。各型肝炎病毒男女感染率无明显差异。献浆次数、年限与HCV、HEV、HGV感染呈正相关。HBsAg、抗-HBc、抗-HCV呈现家庭聚集性，但仅HBsAg呈现母亲与子女相关。抗-HCV阳性者中ALT异常率(15.9%)显著高于抗-HCV阴性者(1.2%，P<0.01)。结论 该人群甲、乙、丙、戊和庚型肝炎病毒感染具有不同的流行病学特点；献血浆是该人群HCV、HEV和HGV感染的主要危险因素；抗-HCV阳性者多伴有肝损害。
A cross-sectional study onHAV,HBV,HCV,HEV and HGV infection in a rural population
CUI Yihui,ZHUANG Hui,SUN Degui,etal.
Department of Microbiology,BeijingMedical University,Beijing 100083
【 Abstract 】 Objective To study the epidemiological characteristics ofHAV,HBV,HCV,HEV and HGV infections in a rural population. Methods Enzyme immunoassays were used for detection of anti-HAV,HBsAg,anti-HBs,anti-HCV,anti-HEV and anti-HGV. Anti-HGV positive sera werefurther tested for HGV RNA using a reverse transcription nested PCR. Results The prevalence rates of anti-HAV,HBsAg,anti-HCV,anti-HEV,anti-HGV in the studied population were86.9%,8.0%,11.5%,2.9% and 1.8%,respectively. The total infection rate of HBV was 54.8%.The HAV infection rate of children below 5 was the lowest (35.0%) as compared with otherage groups. 85.0% of children at 10 years old had already been infected with HAV. TheHBsAg positive rate showed two peaks at 5-9 and 40-49 age groups. The total infection rateof HBV was 55.0% in the age group less than 10 years old and increased with age. HCVinfection mainly occurred in the age group of 20-49 (77.8%). The prevalence rates of anti-HCV,anti-HEV and anti-HGV increased with the frequencies and duration of plasmadonation. Family clusterings of HBsAg,anti-HBc and anti-HCV were observed. However,onlywith HBsAg showed a correlation between mothers and their offspring.The frequency ofabnormal ALT in anti-HCV positiveindividuals was significantly higher as compared with that in those with negative anti-HCV. No difference was observed in the frequencies of elevated ALT between those withor without HAV,HBV,HEV and HGV markers. Conclusion HAV,HBV,HCV,HEV and HGV infections had differentepidemiological characteristics. Plasma donation was the major risk factor for HCV,HEV andHGV infections in this population under study. Anti-HCV positive individuals are morelikely to have active HCV infection.
......
您现在查看是摘要页，全文长 14825 字符。