【摘要】 目的 探索肺炎支原体所致下呼吸道感染的免疫学发病机制。方法 采用顺序饱和液相竞争放射免疫分析法及夹心酶免疫放射分析法对30例肺炎支原体所致下呼吸道感染患儿血清进行了肿瘤坏死因子(TNF)-α和白细胞介素-8(IL-8)的检测。结果 肺炎支原体所致下呼吸道感染患儿血清中TNF-α及IL-8水平均明显高于健康儿童；TNF-α和IL-8升高呈正相关。结论 TNF-α在肺炎支原体所致下呼吸道感染中起着重要作用，也是IL-8升高的重要促进因子。

    

【Abstract】 Objective To investigate theimmunopatholog ical mechanism of LRTI caused by Mycoplasma pneumonia. Methods Serumtumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) from 30 patients with LRTIcaused by Mycoplasma pneumonia, were measured wit h sequence saturated solutioncompetitive radioimmunoassay and sandwich ELISA. Results The level ofserum TNF-α and IL-8 of patients su ffering from LRTI caused by Mycoplasma pneumonia weremagnificently higher t han that of healthy children. Meanwhile, a positive relationshipbetween serum T NF-α and IL-8 was noticed. Conclusion TNF-α plays anim portant role in LRTI caused by Mycoplasma pneumonia, and serves the key fact or to theelevation of IL-8.

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