摘要 1997年6月北京某写字楼员工发生一起上呼吸道感染样(上感样)疫情。为查明爆发原因，采用流行病学病例-对照调查研究方法，分别对病例组、对照组进行嗜肺军团菌(Lp)抗体1～14型血清学检测，并对大厦空调系统采样进行细菌学培养检测。结果：该次爆发疫情的扁桃体炎罹患率为61.86%，上感罹患率34.62%，统计学检验发热与扁桃体关系密切(χ² =77.88，P<0.01)；上感病例Lp9、10、12、14四型抗体阳性率为45.94%，四组对照前述四种抗体的阳性比例分别为3/15、6/17、0/15、0/16；空调冷凝水培养Lp阳性。证明这是一起以空调系统为媒介由Lp9、12引起的上感样军团菌病爆发。

    

    Investigation of An Legionnaires' Disease OutbreakAssociated with Contaminated Air-Conditioning System Ma Xiaoyan^* ,Wang Yuqin, Peng Xiaoming,et al. ^* Department of Epidemiology ,Beijing Municipal Center for Hygieneand Epidemic Control, Beijing 100013

     Abstract An outbreak of upper respiratory infection (influenza-like syndrom)took place among the staff members of a large office building in Beijing,June, 1997.Tounderstand the cause of the outbreak, with a case-control study with serologicalantibodies detection against serogroup 1 to 14 of Legionnaires' disease bacteria (LDB) andbacteriological test and culture on samples collected from the air-conditioning system ofthe office building was performed. The findings showed that the attack rates oftongillitis and upper respiratory infection were 61.86% and 34.62% respectively. Therelation was statistically significant between the symptoms of fever and tonsillitis inthe cases (χ² =77.88,P<0.01). The positive rates of LDB antibodies on serogroups 9, 10,12,14 were 45.94% in the cases of upper respiratory infection and 3/15,6/17,0/15,1/16respectively in the four controls groups. Condensied water samples from anair-conditioning system showed that Legionella Pneumophila was positive. Evidence showedthat it was an outbreak resulting from LDB serogroup 9 and 12, accompanied by upperrespiratory infection related to air-conditioning system contaminated by LDB. This was thefirst report Lp infection associated with an air-conditioning system in China.

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