施育平 单江 李迪元 傅国胜 310009 杭州，浙江医科大学附属第二医院心内科(施育平、单江、傅国胜)；上海市高血压研究所(李迪元) 中华内科杂志 1998 0 0 12


    关键词：冠状动脉疾病；基因；中国人 期刊 zhnkzz 0 论 著 fur -->


    

【摘要 】 目的 探讨血管紧张素转换酶(ACE)基因多态性在中国人冠心病发生发展中的作用。方法 应用聚合酶链反应技术和遗传学方法，测定159例中国汉族正常人、148例冠心病患者的ACE基因插入/缺失(I/D)多态性频率。结果 (1)中国汉族正常人DD、ID、II基因型频率分别为0.157、0.535和0.308；(2)冠心病组及其心肌梗塞、心绞痛亚组ACE基因型分布与正常人相比差异均有显著性(P<0.05)，其DD型频率分别为0.264、0.278和0.250，均显著高于正常人(P<0.05)；(3)冠状动脉造影确诊的冠心病患者ACEDD基因型频率在单支、双支和多支病变组分别为0.250、0.222和0.400，多支血管病变较单支病变有增高的趋势，但差异无显著性(P>0.05)；(4)冠心病心功能Ⅰ～Ⅱ级患者、Ⅲ～Ⅳ级患者ACEDD基因型频率分别为0.207和0.357，心功能Ⅲ～Ⅳ级患者的DD型频率显著高于心功能Ⅰ～Ⅱ级患者(P<0.05)。结论 ACE基因缺失多态性可能与中国人冠心病的发生与发展有关；DD基因型可能是冠心病预后不良的一个标记。

Association of angiotensinconverting enzyme gene polymorphism with coronary heart disease in Chinese Shi Yuping^* ,Shan Jiang, Li Diyuan, et al. ^* Department of Cardiology, The Second AffilliatedHospital of Zhejiang Medical University, Hangzho u 310009

【 Abstract 】 Objective To investigate the association ofangiotensin converting enzyme (ACE) gene polymorphism with coronary heart disease (CHD) inChinese Han nationality. Methods 148 patients with CHD and 159 unrelated healthyindividuals were studied by using polymorase chain reaction (PCR) and genetic methods. Thepresence or absence of a 287 bp fragment in intron 16 of the gene serves as a marker forthis polymorphism. Results (1) Among the normal subjects, the frequencies of the DD, ID and IIgenotypes was 0.157, 0.535 and 0.308, respectively. (2) The ACE genotypes distribution inCHD patients, as well as myocardial infarction (MI) and angina pectoris (AP) subgroupswere significantly different from that of the normal subjects (P<0.05). The DD genotypefrequencies in CHD, MI and AP groups were 0.264, 0.278 and 0.250, respectively. (3) The DDgenotype frequency in multivessel disease patients were higher than that in single anddouble vessel disease patients (0.400 vs 0.250 and 0.222, P>0.05). (4) Patients withworse heart function (NYHA Class Ⅲ to Ⅳ ) had significantly higher DD frequency than those with better heart function (NYHA Ⅰ to Ⅱ ) (0.357 vs 0.207, P<0.05). Conclusion These results suggest that theACE gene deletion polymorphism is involved in the occurrence and the development of CHD inthe population of Chinese, and DD genotype might be a genetic marker of worse outcome inCHD patients.

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