【摘要】 目的 调查中国人群中抗流感嗜血杆菌多糖(Hib-PRP)自然抗体水平，为合理使用Hib菌苗提供资料。方法 从7个省市收集1596份不同年龄组健康人群血清标本，用放射免疫方法检测抗Hib-PRP自然抗体水平。结果 甘肃、贵州、江西等地5岁以下婴幼儿平均抗体水平<0.1μg/ml，上海、广西、黑龙江等地相对较高。脐带血平均抗体含量为0.36μg/ml，6月～5岁儿童平均抗体含量为<0.15μg/ml，6岁至成人则达1～1.5μg/ml。结论 中国人群对Hib疾病的群体免疫力不高。6月～5岁儿童自然抗体水平最低，为Hib疾病的高危人群。

    

【Abstract】 Objective Investigation ofnatural antibody level to Haemophilus influenzae type b polysaccharide in China. Methods 1 596 sera samples from cord (55 sera), infants (1 383 s era), children (66sera), adult (52 sera) and elderly (40 sera) were collected f rom different provinces andthe natural antibody level to PRP was measured with a standardized radio immunoassay ¹²⁵ I-labeled PRP. Results Antibody level of infants under 5 year olds in differentprovinces was different. Levels of infants from Gansu, Guizhou, Jiangxi province werelower ( ≤0.07 μg/ml) than from Shanhai, Guangxi and Heilognjiang. Comparison ofantibody leve ls with different age groups showed that infants aged 6 months to 5 yearshaving the lowest antibody level (<0.15μg/ml). The level increased rapidly during 6- 10years of age (≥1.0μg/ml). The levels of adults and elderly were about 1-1.5 μg/ml. Conclusion General immunity against Hib disease were low in Chinese population.Children aged 6 months to 5 years old with lowes t natural antibody level to PRP were thepopulation under high risk .

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