马景学 Gisbert Richard Ulrich Schaudig Alexander A.Bialasiewicz 050000 石家庄，河北医科大学第二医院眼科(马景学)；德国汉堡大学眼科医院(Richard G、Schaudig U、Bialasiewicz AA) 中华眼底病杂志 1999 0 15 4


    关键词：硅油类/副作用；眼/病理学 期刊 zhydbzz 0 论著 fur -->


    

【摘要 】 目的 探讨硅油对人眼内组织毒副作用的发生时间及机制。 方法 对19例因硅油填充术后严重并发症而摘除的眼球进行组织病理学观察。 结果 在感觉层视网膜、视网膜色素上皮(retinal pigment epithelium,RPE)细胞、视神经、视网膜前膜和下膜、虹膜、前房角、以及角膜内皮中均可见硅油小泡或小滴。在硅油填充短于9个月的眼中，硅油小泡仅见于视网膜表面(视网膜前膜及巨噬细胞内)；硅油填充9个月以上的眼中，硅油小泡进入感觉层视网膜内。1例硅油填充39个月的眼中，视神经间质和蛛网膜下间隙受到硅油小泡弥漫性浸润。 结论 眼内硅油填充术后的并发症与硅油在眼内存留的时间长短有关。

    中国图书资料分类法分类号 R779.6 R361.2

Ocular histopathologic findings after intravitreal silicone tamponade

MA Jingxue^* ,Gisbert Richard,Ulrich Schaudig,et al.^*

    Department of Ophthalmology,the Second Affiliated Hospital of Hebei Medical University,Shijiazhuang 050000,China

【Abstract 】 Objective To investigate the time and the mechanism of the toxic and side effects of silicone oil on ocular tissues. Methods 19 human eyeballs were examined histopathologically at different time intervals after silicone oil tamponade. Results Microscopic bubbles presumably containing silicone oil were found in sensory retina,RPE,optic nerve,pre- and subretinal membrane,iris,anterior chamber angle,and retrocorneal membrane.In the eyes containing silicone oil for less than 9 months.Silicone bubbles were present only in the surface of retina(within preretinal membrane or macrophages),and after that time,silicone bubbles were noted within sensory retina.In an eye enucleated 39 months after intravitreal silicone tamponade,the parenchyma and subarachnoid space of the optic nerve were found to be diffusely invaded by silicone bubbles. Conclusion The histopathologic changes of ocular tissues are related to the duration of intravitreal silicone oil tamponade.

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