玻璃体视网膜病变，增生性_病理学

增生性玻璃体视网膜病变玻璃体切割物的细胞凋亡观察

http://www.100md.com 《中华眼底病杂志》 1999年第2期

玻璃体视网膜病变，增生性,病理学|细胞死亡,关键词：

     杨桦管红兵张皙陈伟吴乃川顾青 200080 上海市第一人民医院眼科，上海市眼科研究所(杨桦、张皙、陈伟、吴乃川)，中心实验室(管红兵、顾青) 中华眼底病杂志 1999 0 15 2

    关键词：玻璃体视网膜病变，增生性/病理学；细胞死亡期刊 zhydbzz 0 增生性玻璃体视网膜病变研究 fur -->

【摘要】目的 观察增生性玻璃体视网膜病变玻璃体切割物的细胞凋亡情况。方法收集60例不同分级的增生性玻璃体视网膜病变患者的玻璃体切割物，核苷酸末端转移酶介导dUTP缺口翻译法(TdT-mediated dUTP nick end labelling method，TUNEL法)标记凋亡细胞，光镜观察。结果 60例患者的玻璃体切割物均有细胞凋亡的特征性改变，随着病变程度的加重，非色素细胞凋亡总数逐渐减少，并出现色素细胞凋亡。结论增生性玻璃体视网膜病变存在不同类型细胞的凋亡，细胞凋亡是调控其病变程度的重要机制之一。

The observation on apoptosis from vitrectomy specimens of proliferative vitreoretinopathy

YANG Hua,GUAN Hongbing,ZHANG Xi,et al.Department of Ophthalmology,Shanghai Eye Research Institute,Shanghai First Peoples Hospital,Shanghai Medical University,Shanghai 200080,China

【Abstract】 Purpose To investigate apoptosis in vitrectomy specimens of proliferative vitreoretinopathy. Methods Vitrectomy specimens from 60 cases of different classes of proliferative vitreoretinopathy were studied by TdT-mediated dUTP nick end labelling(TUNEL)method. Results The characteristic change of apoptosis was observed in all vitrectomy specimens.The amount of apoptotic non-pigmentary cell is gradually decreasing along with the development of proliferative vitreoretinopathy,and apoptotic pigmentary cells are observed. Conclusion There are different kinds of apoptosis cell in vitrectomy specimens of proliferative vitreoretinopathy.It is suggested that apoptosis might be one of the important mechanisms of regulating the degree in proliferative vitreoretinopathy.

【Key words】 Vitreoretinopathy ......

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